Hendrikus Duifhuis Cochlear Mechanics

Annotation

The field of cochlear mechanics has received an increasing interest over the last few decades. In the majority of these studies the researchers use linear systems analysis or linear approximations of the nonlinear (NL) systems. Even though it has been clear that the intact cochlea operates nonlinearly, lack of tools for proper nonlinear analysis, and widely available tools for linear analysis still lead to inefficient and probably incorrect interpretation of the biophysics of the cochlea. An example is the presumption that a change in cochlear stiffness (at hair cell level) must account for the observed change in tuning (or frequency mapping) due (e.g.) prestin application. Misconceptions like this need to be addressed in a tutorial that is lucid enough to explain basic differences between linear and nonlinear cochleae at a graduate level. This book presents a useful and mathematically justified/justifiable approach in the main part of the text, an approach that will be elucidated with clear examples. The book will be useful to scientists in auditory neuroscience, as well as graduate students in biophysics/biomedical engineering.