Edward A. Bump, Kamal Malaker Radioprotectors

Annotation

It is essential to minimize damage to normal tissues during radiation therapy and many strategies have been employed in finding the best methods for radioprotection. This book integrates chemical, biological, and clinical perspectives on these strategies and developments, providing a comprehensive treatise. It emphasizes new concepts in radioprotection, aiming to inspire further basic science and clinical progress in radioprotector research. Radioprotectors: Chemical, Biological, and Clinical Perspectives includes the following topics:Early research on radioprotectorsWR-2721, an aminothiol prodrug, as a radioprotectorNew results with naturally occurring thiolsNitroxides as effective radioprotectors in vitro and in vivoRadioprotection observed with radical scavengers or antioxidantsBone marrow radioprotection with cytokines and biological modifiersMultiple mechanisms of altering radiation response by eicosanoidsVascular response to radiation and the importance of vascular damage to normal tissue Modifiers of radiation-induced apoptosisSurvey of clinical trials with radioprotectorsRadiation biologists and oncologists, cancer researchers, and toxicologists will benefit from the findings discussed and strategies for future research.